Endocrine Abstracts

This is the review of original data concerning the role of some metabolic hormones (GH, leptin, ghrelin, obestatin), growth factors (IGF-I, IGFBPs, EGF, thrombopoietin), intracellular mediators of their action (cyclic nucleotides, protein kinases, PKA, MAPK, CDK, transcription factors, CREB, STAT-1, p53 and related cDNA, siRNA and miRNA gene constructs) on basic ovarian functions (cell proliferation, apoptosis, secretion, oogenesis, ovulation, production and viability of pups)...

When patient was an 14-year-old, he presented with a short stature and underdeveloped external genitalia. The patient had not undergone normal pubertal development. Hormonal studies and clinical examination revealed the findings of anterior and posterior pituitary hormone deficiency: ADH, LH (0.2 mIU/l), FSH (1.22 mIU/l). Since then patient took different therapy for diabetes insipidus. Secondary sexual characters developed during patient received gonadotropin for a very short...

Introduction: Anti-epileptic drugs (AED) adversely affecting bone health. However, individual variations between different AEDs exist and not all AEDs are equally toxic to the bone. There is almost equipoise about the effect of valproate on bone.Methods: We conducted a cross-sectional study assessing bone mineral density with dual energy X-ray absorptiometry at the hip and lumbar spine in 33 outpatients receiving valproate for ≥1 year and 36 health...

Objectives: Long-term results of medical treatment of macroprolactinoma in children and adolescents (<20 years).Patients and methods: Retrospective analysis of all the cases of macroprolactinoma occurring in children and adolescents, medically treated in two university centers.Results: 38 patients, 25 girls 13 boys, age at diagnosis: 15.7±2.8 years (only two cases before 12 years). At diagnosis, 2/3 presented with headache...